department of defense duchenne muscular dystrophy research program: investigator-initiated research award
fy17 dmdrp program announcements and general application instructions for the following award mechanisms are posted on grants.gov.
as directed by the office of the assistant secretary of defense for health affairs, the defense health agency (dha) j9, research and development directorate manages the defense health program (dhp) research, development, test, and evaluation (rdt&e) appropriation. the managing agent for the anticipated program announcements/funding opportunities is the congressionally directed medical research programs (cdmrp).
all applications for the fy17 dmdrp funding opportunities are required to address at least one of the following focus areas:
- cardiac studies, including identifying mechanisms of pathology and therapeutic interventions
- clinical studies, novel interventions, and drug and biologic delivery technologies designed to improve clinical care and quality of life in areas such as:
○ cognitive function
○ endocrinology
○ gastrointestinal issues
○ immunology
○ orthopaedics
○ psychosocial issues
○ pulmonology (including sleep-focused studies)
○ skeletal muscle
- assessment of clinical trial tools and outcome measures, such as:
○ discovery and qualification of pharmacodynamic, prognostic, and predictive biomarkers
○ novel clinical outcome assessments
○ patient-centered outcomes, e.g., quality of life, activities of daily living
○ potential surrogate markers
- extension or expansion of existing preclinical translational data in support of a specific therapeutic development path (including drug exposure, independent replication, and comparative studies)
investigator-initiated research award – preapplication due july 19, 2017
principal investigator: must be an independent investigator at or above the level of assistant professor (or equivalent).
optional nested resident or medical student trainee: resident trainee must be enrolled in an accredited residency program. medical student trainee must be enrolled in a nationally accredited (or equivalent) medical school. trainees must be able to devote a minimum of 40% level of effort.
optional multidiscipline collaborator: must be an independent investigator at or above the level of assistant professor (or equivalent).
· supports translational research that will have an impact on improving the function, quality of life, and/or extending the lifespan for all individuals with duchenne.
· supports translational research that will accelerate the movement of promising new ideas in duchenne research in clinical applications.
· optional multidiscipline collaboration: supports projects that include multi-disciplinary collaborations including, but not limited to, the following: immunology, nanotechnology, or orthopaedics. applications that include a multidiscipline collaborator who meets criteria identified in the program announcement/funding opportunity may apply for a higher level of funding.
· clinical trials are allowed.
- preliminary data are required.
· maximum funding of $600,000 for direct costs (plus indirect costs).
· maximum period of performance is 3 years.
· nested traineeship: additional maximum of $50,000 for residents or $30,000 for medical 世界杯2022赛程表淘汰赛 in direct costs (plus indirect costs) over a one-year period of performance.
optional multidiscipline collaboration: additional maximum of $150,000 in direct costs over the 3-year period of performance.