nicholas bel - biotechnology phd defense

you are invite to attend the defense of biotechnology phd candidate, nicholas bel on thursday, aug. 22 at 1 p.m. in cb 4058 or on zoom.

title: role of survivin and sirtuin-1 in antioxidant & redox response in arpe-19 cells

summary: this study aims to investigate the role of oxidative stress and the ability to use natural antioxidant compounds as a means of reducing oxidative stress and mitigating further cellular damages in an in vitro model of age-related macular degeneration. resveratrol, pterostilbene, lutein, punicalagin, loganin, chebulagic acid, beta-carotene, and zeaxanthin were investigated in the cell culture model as a means of offering cytoprotection to arpe-19 in environments of chronic oxidative stress. the study used engineered crispr knockdown cells to investigate the response of antioxidants on survivin and sirtuin-1 reduced human retinal cells (arpe-19 cells).

committee members: dr. neelam khaper (supervisor), dr. christine gottardo, dr. zach suntres, and dr. guangdong yang (external)

everyone is welcome.

please contact brenda magajna at phd.ses@lakeheadu.ca for more information and the zoom link.